Clonal evolution enhances leukemia propagating cell frequency in T-cell acute lymphoblastic leukemia through Akt/mTORC1 pathway activation

SUMMARY: Clonal evolution and intratumoral heterogeneity drive cancer progression through unknown molecular mechanisms. To address this issue, functional differences between single T-cell acute lymphoblastic leukemia (T-ALL) clones were assessed using a zebrafish transgenic model. Functional variati...

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Huvudupphovsmän: Blackburn, Jessica S., Liu, Sali, Wilder, Jayme L., Dobrinski, Kimberly P., Lobbardi, Riadh, Moore, Finola E., Martinez, Sarah A., Chen, Eleanor Y., Lee, Charles, Langenau, David M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992437/
https://ncbi.nlm.nih.gov/pubmed/24613413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.01.032
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