Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death

Genome-wide association studies can identify common differences that contribute to human phenotypic diversity and disease. When genome-wide association studies are combined with approaches that test how variants alter physiology, biological insights can emerge. Here, we used such an approach to reve...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Ko, Dennis C., Gamazon, Eric R., Shukla, Kajal P., Pfuetzner, Richard A., Whittington, Dale, Holden, Tarah D., Brittnacher, Mitchell J., Fong, Christine, Radey, Matthew, Ogohara, Cassandra, Stark, Amy L., Akey, Joshua M., Dolan, M. Eileen, Wurfel, Mark M., Miller, Samuel I.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2012
Gaiak:
PNAS Plus
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3435171/
https://ncbi.nlm.nih.gov/pubmed/22837397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206701109
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