Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death

Genome-wide association studies can identify common differences that contribute to human phenotypic diversity and disease. When genome-wide association studies are combined with approaches that test how variants alter physiology, biological insights can emerge. Here, we used such an approach to reve...

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Detalhes bibliográficos
Main Authors: Ko, Dennis C., Gamazon, Eric R., Shukla, Kajal P., Pfuetzner, Richard A., Whittington, Dale, Holden, Tarah D., Brittnacher, Mitchell J., Fong, Christine, Radey, Matthew, Ogohara, Cassandra, Stark, Amy L., Akey, Joshua M., Dolan, M. Eileen, Wurfel, Mark M., Miller, Samuel I.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3435171/
https://ncbi.nlm.nih.gov/pubmed/22837397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206701109
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