Met receptor tyrosine kinase signals through a cortactin–Gab1 scaffold complex, to mediate invadopodia

Invasive carcinoma cells form actin-rich matrix-degrading protrusions called invadopodia. These structures resemble podosomes produced by some normal cells and play a crucial role in extracellular matrix remodeling. In cancer, formation of invadopodia is strongly associated with invasive potential....

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Autores principales: Rajadurai, Charles V., Havrylov, Serhiy, Zaoui, Kossay, Vaillancourt, Richard, Stuible, Matthew, Naujokas, Monica, Zuo, Dongmei, Tremblay, Michel L., Park, Morag
Formato: Artigo
Lenguaje:Inglês
Publicado: The Company of Biologists 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434810/
https://ncbi.nlm.nih.gov/pubmed/22366451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.100834
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