Glucocorticoid resistance in chronic lymphocytic leukaemia is associated with a failure of upregulated Bim/Bcl-2 complexes to activate Bax and Bak

Glucocorticoids (GCs) represent an important component of modern treatment regimens for fludarabine-refractory or TP53-defective chronic lymphocytic leukemia (CLL). However, GC therapy is not effective in all patients. The molecular mechanisms responsible for GC-induced apoptosis and resistance were...

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Detalhes bibliográficos
Main Authors: Melarangi, T, Zhuang, J, Lin, K, Rockliffe, N, Bosanquet, A G, Oates, M, Slupsky, J R, Pettitt, A R
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434667/
https://ncbi.nlm.nih.gov/pubmed/22898870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.102
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