Anti-apoptotic gene Bcl2 is required for stapes development and hearing

In this paper we describe novel and specific roles for the apoptotic regulators Bcl2 and Bim in hearing and stapes development. Bcl2 is anti-apoptotic while Bim is pro-apoptotic. Characterization of the auditory systems of mice deficient for these molecules revealed that Bcl2(−/−) mice suffered seve...

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Autors principals: Carpinelli, M R, Wise, A K, Arhatari, B D, Bouillet, P, Manji, S S M, Manning, M G, Cooray, A A, Burt, R A
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434664/
https://ncbi.nlm.nih.gov/pubmed/22874999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.100
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