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The Sphingosine-1-Phosphate Analogue FTY720 Impairs Mucosal Immunity and Clearance of the Enteric Pathogen Citrobacter rodentium

The sphingosine-1-phosphate (S1P) analogue FTY720 is therapeutically efficacious in multiple sclerosis and in the prevention of transplant rejection. It prevents the migration of lymphocytes to sites of pathology by trapping them within the peripheral lymph nodes, mesenteric lymph nodes (MLNs), and...

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Detalhes bibliográficos
Main Authors: Murphy, Carola T., Hall, Lindsay J., Hurley, Grainne, Quinlan, Aoife, MacSharry, John, Shanahan, Fergus, Nally, Kenneth, Melgar, Silvia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434556/
https://ncbi.nlm.nih.gov/pubmed/22615252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.06319-11
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