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The Sphingosine-1-Phosphate Analogue FTY720 Impairs Mucosal Immunity and Clearance of the Enteric Pathogen Citrobacter rodentium

The sphingosine-1-phosphate (S1P) analogue FTY720 is therapeutically efficacious in multiple sclerosis and in the prevention of transplant rejection. It prevents the migration of lymphocytes to sites of pathology by trapping them within the peripheral lymph nodes, mesenteric lymph nodes (MLNs), and...

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Détails bibliographiques
Auteurs principaux: Murphy, Carola T., Hall, Lindsay J., Hurley, Grainne, Quinlan, Aoife, MacSharry, John, Shanahan, Fergus, Nally, Kenneth, Melgar, Silvia
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2012
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434556/
https://ncbi.nlm.nih.gov/pubmed/22615252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.06319-11
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