Dissecting DNA damage response pathways by analyzing protein localization and abundance changes during DNA replication stress

Re-localization of proteins is a hallmark of the DNA damage response. We use high-throughput microscopic screening of the yeast GFP fusion collection to develop a systems-level view of protein re-organization following drug-induced DNA replication stress. Changes in protein localization and abundanc...

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Bibliographic Details
Main Authors: Tkach, Johnny M., Yimit, Askar, Lee, Anna Y., Riffle, Michael, Costanzo, Michael, Jaschob, Daniel, Hendry, Jason A., Ou, Jiongwen, Moffat, Jason, Boone, Charles, Davis, Trisha N., Nislow, Corey, Brown, Grant W.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434236/
https://ncbi.nlm.nih.gov/pubmed/22842922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2549
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