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An autoregulatory loop reverts the mechanosensitive Sirt1 induction by EGR1 in skeletal muscle cells

Muscle contraction is associated with the production of reactive oxygen species (ROS). Mechanisms of ROS scavenging are fundamental to avoid muscle damage. We had previously discovered a stretch-induced genetic program in myotubes that triggers an antioxidant defense. At the core of this mechanism,...

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Detalhes bibliográficos
Main Authors: Pardo, Patricia S., Boriek, Aladin M.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433932/
https://ncbi.nlm.nih.gov/pubmed/22820707
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