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La Autoantigen Mediates Oxidant Induced De Novo Nrf2 Protein Translation

Nrf2 gene encodes a transcription factor that regulates the expression of a cluster of antioxidant and detoxification genes. Recent works from our laboratory indicate that oxidative stress causes rapid de novo synthesis of Nrf2 protein. We have found that 5′ Untranslated Region (5′UTR) of Nrf2 allow...

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Autors principals: Zhang, Jack, Dinh, Thai Nho, Kappeler, Kyle, Tsaprailis, George, Chen, Qin M.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433904/
https://ncbi.nlm.nih.gov/pubmed/22207702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M111.015032
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