Multivalent di-nucleosome recognition enables the Rpd3S histone deacetylase complex to tolerate decreased H3K36 methylation levels

The Rpd3S histone deacetylase complex represses cryptic transcription initiation within coding regions by maintaining the hypo-acetylated state of transcribed chromatin. Rpd3S recognizes methylation of histone H3 at lysine 36 (H3K36me), which is required for its deacetylation activity. Rpd3S is able...

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Main Authors: Huh, Jae-Wan, Wu, Jun, Lee, Chul-Hwan, Yun, Miyong, Gilada, Daniel, Brautigam, Chad A, Li, Bing
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433781/
https://ncbi.nlm.nih.gov/pubmed/22863776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.221
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