The molecular basis for high affinity of a universal ligand for human bombesin receptor (BnR) family members

There is increased interest in the Bn-receptor family because they are frequently over/ectopically-expressed by tumors and thus useful as targets for imaging or receptor-targeted-cytotoxicity. The synthetic Bn-analog,[D-Tyr(6),β-Ala(11),Phe(13),Nle(14)]Bn(6-14)[Univ.Lig] has the unique property of h...

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Hlavní autoři: Uehara, Hirotsugu, Hocart, Simon J., González, Nieves, Mantey, Samuel A., Nakagawa, Tomoo, Katsuno, Tatsuro, Coy, David H., Jensen, Robert T.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433740/
https://ncbi.nlm.nih.gov/pubmed/22828605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2012.07.010
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