PPAR-γ Regulates Carnitine Homeostasis and Mitochondrial Function in a Lamb Model of Increased Pulmonary Blood Flow

OBJECTIVE: Carnitine homeostasis is disrupted in lambs with endothelial dysfunction secondary to increased pulmonary blood flow (Shunt). Our recent studies have also indicated that the disruption in carnitine homeostasis correlates with a decrease in PPAR-γ expression in Shunt lambs. Thus, this stud...

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Bibliographic Details
Main Authors: Sharma, Shruti, Sun, Xutong, Rafikov, Ruslan, Kumar, Sanjiv, Hou, Yali, Oishi, Peter E., Datar, Sanjeev A., Raff, Gary, Fineman, Jeffrey R., Black, Stephen M.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433474/
https://ncbi.nlm.nih.gov/pubmed/22962578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041555
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