Cell Model of Catecholaminergic Polymorphic Ventricular Tachycardia Reveals Early and Delayed Afterdepolarizations

BACKGROUND: Induced pluripotent stem cells (iPSC) provide means to study the pathophysiology of genetic disorders. Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a malignant inherited ion channel disorder predominantly caused by mutations in the cardiac ryanodine receptor (RyR2). In...

Full description

Saved in:
Bibliographic Details
Main Authors: Kujala, Kirsi, Paavola, Jere, Lahti, Anna, Larsson, Kim, Pekkanen-Mattila, Mari, Viitasalo, Matti, Lahtinen, Annukka M., Toivonen, Lauri, Kontula, Kimmo, Swan, Heikki, Laine, Mika, Silvennoinen, Olli, Aalto-Setälä, Katriina
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433449/
https://ncbi.nlm.nih.gov/pubmed/22962621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0044660
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items