Antiarrhythmic Effects of Dantrolene in Patients with Catecholaminergic Polymorphic Ventricular Tachycardia and Replication of the Responses Using iPSC Models

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a highly malignant inherited arrhythmogenic disorder. Type 1 CPVT (CPVT1) is caused by cardiac ryanodine receptor (RyR2) gene mutations resulting in abnormal calcium release from sarcoplasmic reticulum. Dantrolene, an inhibitor of sarco...

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Pubblicato in:PLoS One
Autori principali: Penttinen, Kirsi, Swan, Heikki, Vanninen, Sari, Paavola, Jere, Lahtinen, Annukka M., Kontula, Kimmo, Aalto-Setälä, Katriina
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4425399/
https://ncbi.nlm.nih.gov/pubmed/25955245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0125366
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