Substituent effects on P2-cyclopentyltetrahydrofuranyl urethanes: Design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors

The design, synthesis, and biological evaluation of novel C3-substituted cyclopentyltetrahydrofuranyl (Cp-THF)-derived HIV-1 protease inhibitors are described. Various C3-functional groups on the Cp-THF ligand were investigated in order to maximize the ligand-binding site interactions in the flap re...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Ghosh, Arun K., Chapsal, Bruno D., Steffey, Melinda, Agniswamy, Johnson, Wang, Yuan-Fang, Amano, Masayuki, Weber, Irene T., Mitsuya, Hiroaki
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433276/
https://ncbi.nlm.nih.gov/pubmed/22364812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.01.061
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados