Caricamento...

Design of HIV-1 Protease Inhibitors with C3-Substituted Hexahydrocyclopentafuranyl Urethanes as P2-Ligands: Synthesis, Biological Evaluation, and Protein-Ligand X-ray Crystal Structure

We report the design, synthesis, biological evaluation, and the X-ray crystal structure of a novel inhibitor-bound HIV-1 protease. Various C3-functionalized cyclopentanyltetrahydrofurans (Cp-THF) were designed to interact with the flap Gly48 carbonyl or amide NH in the S2-subsite of the HIV-1 protea...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Ghosh, Arun K., Chapsal, Bruno D., Parham, Garth L., Steffey, Melinda, Agniswamy, Johnson, Wang, Yuan-Fang, Amano, Masayuki, Weber, Irene T., Mitsuya, Hiroaki
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164320/
https://ncbi.nlm.nih.gov/pubmed/21800876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200649p
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !