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Synthesis and Biological Characterization of Protease-Activated Prodrugs of Doxazolidine
Doxazolidine (doxaz) is a new anthracycline anticancer agent. While structurally similar to doxorubicin (dox), doxaz acts via a distinct mechanism to selectively enhance anticancer activity over cardiotoxicity, the most significant clinical impediment to successful anthracycline treatment. Here, we...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3433255/ https://ncbi.nlm.nih.gov/pubmed/22742660 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300714p |
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