CARBOXYLESTERASE-2 IS A HIGHLY SENSITIVE TARGET OF THE ANTIOBESITY AGENT ORLISTAT WITH PROFOUND IMPLICATIONS IN THE ACTIVATION OF ANTICANCER PRODRUGS

Orlistat has been the most used anti-obesity drug and the mechanism of its action is to reduce lipid absorption by inhibiting gastrointestinal lipases. These enzymes, like carboxylesterases (CESs), structurally belong to the α/β hydrolase fold superfamily. Lipases and CESs are functionally related a...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Xiao, Da, Shi, Deshi, Yang, Dongfang, Barthel, Benjamin, Koch, Tad H., Yan, Bingfang
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4102434/
https://ncbi.nlm.nih.gov/pubmed/23228697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2012.11.026
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares