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Doxazolidine Induction of Apoptosis by a Topoisomerase II-independent Mechanism
The mechanism of doxorubicin is compared with that of doxazolidine, a doxorubicin-formaldehyde conjugate. The IC(50) for growth inhibition of 67 human cancer cell lines, but not cardiomyocytes, is 32-fold lower with doxazolidine than with doxorubicin. Growth inhibition by doxazolidine correlates bet...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2919335/ https://ncbi.nlm.nih.gov/pubmed/17696516 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm070569b |
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