High levels of Hdmx promote cell growth in a subset of uveal melanomas

The p53 tumor suppressor pathway is inactivated in cancer either via direct mutation or via deregulation of upstream regulators or downstream effectors. P53 mutations are rare in uveal melanoma. Here we investigated the role of the p53 inhibitor Hdmx in uveal melanoma. We found Hdmx over-expression...

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Bibliographische Detailangaben
Hauptverfasser: de Lange, Job, Teunisse, Amina FAS, Vries, Matty Verlaan-de, Lodder, Kirsten, Lam, Suzanne, Luyten, Gregorius PM, Bernal, Federico, Jager, Martine J, Jochemsen, Aart G
Format: Artigo
Sprache:Inglês
Veröffentlicht: e-Century Publishing Corporation 2012
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433101/
https://ncbi.nlm.nih.gov/pubmed/22957303
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