Transplanted bone marrow mononuclear cells and MSCs impart clinical benefit to children with osteogenesis imperfecta through different mechanisms

Transplantation of whole bone marrow (BMT) as well as ex vivo–expanded mesenchymal stromal cells (MSCs) leads to striking clinical benefits in children with osteogenesis imperfecta (OI); however, the underlying mechanism of these cell therapies has not been elucidated. Here, we show that non–(plasti...

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Detalhes bibliográficos
Main Authors: Otsuru, Satoru, Gordon, Patricia L., Shimono, Kengo, Jethva, Reena, Marino, Roberta, Phillips, Charlotte L., Hofmann, Ted J., Veronesi, Elena, Dominici, Massimo, Iwamoto, Masahiro, Horwitz, Edwin M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433095/
https://ncbi.nlm.nih.gov/pubmed/22829629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-12-400085
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