Critical role of CD4 T cells in maintaining lymphoid tissue structure for immune cell homeostasis and reconstitution

Loss of the fibroblastic reticular cell (FRC) network in lymphoid tissues during HIV-1 infection has been shown to impair the survival of naive T cells and limit immune reconstitution after antiretroviral therapy. What causes this FRC loss is unknown. Because FRC loss correlates with loss of both na...

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Bibliographic Details
Main Authors: Zeng, Ming, Paiardini, Mirko, Engram, Jessica C., Beilman, Greg J., Chipman, Jeffrey G., Schacker, Timothy W., Silvestri, Guido, Haase, Ashley T.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2012
Subjects:
Immunobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433090/
https://ncbi.nlm.nih.gov/pubmed/22613799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-03-418624
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