Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia

Chromosome maintenance protein 1 (CRM1) is a nuclear export receptor involved in the active transport of tumor suppressors (eg, p53 and nucleophosmin) whose function is altered in cancer because of increased expression and overactive transport. Blocking CRM1-mediated nuclear export of such proteins...

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Main Authors: Ranganathan, Parvathi, Yu, Xueyan, Na, Caroline, Santhanam, Ramasamy, Shacham, Sharon, Kauffman, Michael, Walker, Alison, Klisovic, Rebecca, Blum, William, Caligiuri, Michael, Croce, Carlo M., Marcucci, Guido, Garzon, Ramiro
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2012
Teme:
Plenary Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433086/
https://ncbi.nlm.nih.gov/pubmed/22677130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-04-423160
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