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Targeting MicroRNAs in Cancer: Rationale, Strategies and Challenges

MicroRNAs (miRNAs) are evolutionary conserved small non-coding RNAs that regulate gene expression. Early studies have shown that miRNA expression is deregulated in cancer, and experimental data indicate that cancer phenotypes can be modified by targeting miRNA expression. Based on these observations...

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Hlavní autoři: Garzon, Ramiro, Marcucci, Guido, Croce, Carlo M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904431/
https://ncbi.nlm.nih.gov/pubmed/20885409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrd3179
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