Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment

Hepatitis C virus (HCV) is a major causative agent of chronic liver disease in humans. To gain insight into host factor requirements for HCV replication we performed a siRNA screen of the human kinome and identified 13 different kinases, including phosphatidylinositol-4 kinase III alpha (PI4KIIIα) a...

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Autors principals: Reiss, Simon, Rebhan, Ilka, Backes, Perdita, Romero-Brey, Ines, Erfle, Holger, Matula, Petr, Kaderali, Lars, Poenisch, Marion, Blankenburg, Hagen, Hiet, Marie-Sophie, Longerich, Thomas, Diehl, Sarah, Ramirez, Fidel, Balla, Tamas, Rohr, Karl, Kaul, Artur, Bühler, Sandra, Pepperkok, Rainer, Lengauer, Thomas, Albrecht, Mario, Eils, Roland, Schirmacher, Peter, Lohmann, Volker, Bartenschlager, Ralf
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433060/
https://ncbi.nlm.nih.gov/pubmed/21238945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2010.12.002
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