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N-terminal deletion does not affect α-synuclein membrane binding, self-association and toxicity in human neuroblastoma cells, unlike yeast

α-Synuclein causes Parkinson’s disease if mutated or aberrantly produced in neurons. α-Synuclein–lipid interactions are important for the normal function of the protein, but can also contribute to pathogenesis. We previously reported that deletion of the first 10 N-terminal amino acids dramatically...

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Autors principals: Vamvaca, Katherina, Lansbury, Peter T., Stefanis, Leonidas
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3432859/
https://ncbi.nlm.nih.gov/pubmed/21848810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2011.07431.x
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