Bisphosphonates Improve Trabecular Bone Mass and Normalize Cortical Thickness in Ovariectomized, Osteoblast Connexin43 Deficient Mice

The gap junction protein, connexin43 (Cx43) controls both bone formation and osteoclastogenesis via osteoblasts and/or osteocytes. Cx43 has also been proposed to mediate an anti-apoptotic effect of bisphosphonates, potent inhibitors of bone resorption. We studied whether bisphosphonates are effectiv...

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Main Authors: Watkins, Marcus P., Norris, Jin Yi, Grimston, Susan K., Zhang, Xiaowen, Phipps, Roger J., Ebetino, Frank H., Civitelli, Roberto
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3432742/
https://ncbi.nlm.nih.gov/pubmed/22750450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2012.06.018
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