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Low-density lipoprotein receptor-related protein 1: a physiological Aβ homeostatic mechanism with multiple therapeutic opportunities

Low-density lipoprotein receptor-related protein-1 (LRP1) is the main cell surface receptor involved in brain and systemic clearance of the Alzheimer's disease (AD) toxin amyloid-beta (Aβ). In plasma, a soluble form of LRP1 (sLRP1) is the major transport protein for peripheral Aβ. LRP1 in brain...

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Bibliografski detalji
Glavni autori: Sagare, Abhay P., Deane, Rashid, Zlokovic, Berislav V.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3432694/
https://ncbi.nlm.nih.gov/pubmed/22820095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pharmthera.2012.07.008
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