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Degradable Conjugates from Oxanorbornadiene Reagents
Oxanorbornadienedicarboxylate (OND) reagents were explored for purposes of binding and releasing drugs from serum albumins as representative macromolecular carriers. Being highly reactive Michael acceptors, ONDs form adducts with thiols and amines, which then undergo retro-Diels–Alder fragmentation....
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3432588/ https://ncbi.nlm.nih.gov/pubmed/22455380 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja301491h |
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