Progression to Adrenocortical Tumorigenesis in Mice and Humans through Insulin-Like Growth Factor 2 and β-Catenin

Dysregulation of the WNT and insulin-like growth factor 2 (IGF2) signaling pathways has been implicated in sporadic and syndromic forms of adrenocortical carcinoma (ACC). Abnormal β-catenin staining and CTNNB1 mutations are reported to be common in both adrenocortical adenoma and ACC, whereas elevat...

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Détails bibliographiques
Auteurs principaux: Heaton, Joanne H., Wood, Michelle A., Kim, Alex C., Lima, Lorena O., Barlaskar, Ferdous M., Almeida, Madson Q., Fragoso, Maria C.B.V., Kuick, Rork, Lerario, Antonio M., Simon, Derek P., Soares, Ibere C., Starnes, Elisabeth, Thomas, Dafydd G., Latronico, Ana C., Giordano, Thomas J., Hammer, Gary D.
Format: Artigo
Langue:Inglês
Publié: American Society for Investigative Pathology 2012
Sujets:
Regular Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3432433/
https://ncbi.nlm.nih.gov/pubmed/22800756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.05.026
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