Progression to Adrenocortical Tumorigenesis in Mice and Humans through Insulin-Like Growth Factor 2 and β-Catenin

Dysregulation of the WNT and insulin-like growth factor 2 (IGF2) signaling pathways has been implicated in sporadic and syndromic forms of adrenocortical carcinoma (ACC). Abnormal β-catenin staining and CTNNB1 mutations are reported to be common in both adrenocortical adenoma and ACC, whereas elevat...

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Main Authors: Heaton, Joanne H., Wood, Michelle A., Kim, Alex C., Lima, Lorena O., Barlaskar, Ferdous M., Almeida, Madson Q., Fragoso, Maria C.B.V., Kuick, Rork, Lerario, Antonio M., Simon, Derek P., Soares, Ibere C., Starnes, Elisabeth, Thomas, Dafydd G., Latronico, Ana C., Giordano, Thomas J., Hammer, Gary D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2012
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3432433/
https://ncbi.nlm.nih.gov/pubmed/22800756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.05.026
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