SAT-LB34 Repressive Epigenetic Programs Reinforce Steroidogenic Differentiation and Wnt/β-Catenin Signaling in Aggressive Adrenocortical Carcinoma

Adrenocortical carcinoma (ACC) is a rare, aggressive cancer. Up to 75% of patients develop incurable metastatic disease, highlighting an urgent need for novel medical therapies. We recently identified a rapidly progressive ACC subtype characterized by CpG island hypermethylation (CIMP-high), sustain...

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Bibliografske podrobnosti
izdano v:J Endocr Soc
Main Authors: Mohan, Dipika R, Finco, Isabella, LaPensee, Christopher Ryan, Rege, Juilee, Else, Tobias, Almeida, Madson Q, Vinco, Michelle, Wakamatsu, Alda, Latronico, Ana Claudia, Mendonca, Berenice Bilharinho, Zerbini, Maria Claudia N, Fragoso, Maria Candida Barisson Villares, Rainey, William E, Venneti, Sriram, Marie, Suely K N, Giordano, Thomas J, Lerario, Antonio Marcondes, Hammer, Gary D
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
Adrenal
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7208394/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.2265
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