SAT-LB34 Repressive Epigenetic Programs Reinforce Steroidogenic Differentiation and Wnt/β-Catenin Signaling in Aggressive Adrenocortical Carcinoma

Adrenocortical carcinoma (ACC) is a rare, aggressive cancer. Up to 75% of patients develop incurable metastatic disease, highlighting an urgent need for novel medical therapies. We recently identified a rapidly progressive ACC subtype characterized by CpG island hypermethylation (CIMP-high), sustain...

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Vydáno v:J Endocr Soc
Hlavní autoři: Mohan, Dipika R, Finco, Isabella, LaPensee, Christopher Ryan, Rege, Juilee, Else, Tobias, Almeida, Madson Q, Vinco, Michelle, Wakamatsu, Alda, Latronico, Ana Claudia, Mendonca, Berenice Bilharinho, Zerbini, Maria Claudia N, Fragoso, Maria Candida Barisson Villares, Rainey, William E, Venneti, Sriram, Marie, Suely K N, Giordano, Thomas J, Lerario, Antonio Marcondes, Hammer, Gary D
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Adrenal
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7208394/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.2265
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