SAT-LB34 Repressive Epigenetic Programs Reinforce Steroidogenic Differentiation and Wnt/β-Catenin Signaling in Aggressive Adrenocortical Carcinoma

Adrenocortical carcinoma (ACC) is a rare, aggressive cancer. Up to 75% of patients develop incurable metastatic disease, highlighting an urgent need for novel medical therapies. We recently identified a rapidly progressive ACC subtype characterized by CpG island hypermethylation (CIMP-high), sustain...

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Dettagli Bibliografici
Pubblicato in:J Endocr Soc
Autori principali: Mohan, Dipika R, Finco, Isabella, LaPensee, Christopher Ryan, Rege, Juilee, Else, Tobias, Almeida, Madson Q, Vinco, Michelle, Wakamatsu, Alda, Latronico, Ana Claudia, Mendonca, Berenice Bilharinho, Zerbini, Maria Claudia N, Fragoso, Maria Candida Barisson Villares, Rainey, William E, Venneti, Sriram, Marie, Suely K N, Giordano, Thomas J, Lerario, Antonio Marcondes, Hammer, Gary D
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
Soggetti:
Adrenal
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7208394/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.2265
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