Pathological Features in the Lmna(Dhe/+) Mutant Mouse Provide a Novel Model of Human Otitis Media and Laminopathies

Genetic predisposition is recognized as an important pathogenetic factor in otitis media (OM) and associated diseases. Mutant Lmna mice heterozygous for the disheveled hair and ears allele (Lmna(Dhe/+)) exhibit early-onset, profound hearing deficits and other pathological features mimicking human la...

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Detalhes bibliográficos
Main Authors: Zhang, Yan, Yu, Heping, Xu, Min, Han, Fengchan, Tian, Cong, Kim, Suejin, Fredman, Elisha, Zhang, Jin, Benedict-Alderfer, Cindy, Zheng, Qing Yin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2012
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3432432/
https://ncbi.nlm.nih.gov/pubmed/22819531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.05.031
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