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Interference with RhoA–ROCK Signaling Mechanism in Autoreactive CD4(+) T Cells Enhances the Bioavailability of 1,25-Dihydroxyvitamin D(3) in Experimental Autoimmune Encephalomyelitis

Vitamin D deficiency is a major risk factor for central nervous system (CNS) demyelinating diseases including multiple sclerosis (MS) and its animal model, that of experimental autoimmune encephalomyelitis (EAE). Both vitamin D(3) and 1, 25-dihydroxyviatmin-D(3) (calcitriol) had beneficial effects i...

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Detalhes bibliográficos
Main Authors: Paintlia, Ajaib S., Paintlia, Manjeet K., Hollis, Bruce W., Singh, Avtar K., Singh, Inderjit
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3432427/
https://ncbi.nlm.nih.gov/pubmed/22796435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.05.028
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