Immunomodulatory Effect of Combination Therapy with Lovastatin and 5-Aminoimidazole-4-Carboxamide-1-β-d-Ribofuranoside Alleviates Neurodegeneration in Experimental Autoimmune Encephalomyelitis

Combination therapy with multiple sclerosis (MS) therapeutics is gaining momentum over monotherapy for improving MS. Lovastatin, an HMG-CoA reductase inhibitor (statin), was immunomodulatory in an experimental autoimmune encephalomyelitis (EAE) model of MS. Lovastatin biases the immune response from...

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Detalhes bibliográficos
Main Authors: Paintlia, Ajaib S., Paintlia, Manjeet K., Singh, Inderjit, Singh, Avtar K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2006
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698815/
https://ncbi.nlm.nih.gov/pubmed/16936274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.051309
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