ENaC inhibition stimulates Cl(−) secretion in the mouse cortical collecting duct through an NKCC1-dependent mechanism

In cortical collecting ducts (CCDs) perfused in vitro, inhibiting the epithelial Na(+) channel (ENaC) reduces Cl(−) absorption. Since ENaC does not transport Cl(−), the purpose of this study was to determine how ENaC modulates Cl(−) absorption. Thus, Cl(−) absorption was measured in CCDs perfused in...

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Autori principali: Pech, Vladimir, Thumova, Monika, Kim, Young Hee, Agazatian, Diana, Hummler, Edith, Rossier, Bernard C., Weinstein, Alan M., Nanami, Masayoshi, Wall, Susan M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2012
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431594/
https://ncbi.nlm.nih.gov/pubmed/22496413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00030.2012
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