Deep sequencing of subcellular RNA fractions shows splicing to be predominantly co-transcriptional in the human genome but inefficient for lncRNAs

Splicing remains an incompletely understood process. Recent findings suggest that chromatin structure participates in its regulation. Here, we analyze the RNA from subcellular fractions obtained through RNA-seq in the cell line K562. We show that in the human genome, splicing occurs predominantly du...

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Detalhes bibliográficos
Principais autores: Tilgner, Hagen, Knowles, David G., Johnson, Rory, Davis, Carrie A., Chakrabortty, Sudipto, Djebali, Sarah, Curado, João, Snyder, Michael, Gingeras, Thomas R., Guigó, Roderic
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431479/
https://ncbi.nlm.nih.gov/pubmed/22955974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.134445.111
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https://ncbi.nlm.nih.gov/pmc/articles/PMC3431479/
https://ncbi.nlm.nih.gov/pubmed/22955974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.134445.111