C3a and C5a Promote Renal Ischemia-Reperfusion Injury

Renal ischemia reperfusion injury triggers complement activation, but whether and how the small proinflammatory fragments C3a and C5a contribute to the pathogenesis of this injury remains to be elucidated. Using C3aR-, C5aR-, or C3aR/C5aR-deficient mice and models of renal ischemia-reperfusion injur...

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Detalhes bibliográficos
Main Authors: Peng, Qi, Li, Ke, Smyth, Lesley A., Xing, Guolan, Wang, Naiyin, Meader, Lucy, Lu, Bao, Sacks, Steven H., Zhou, Wuding
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2012
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431410/
https://ncbi.nlm.nih.gov/pubmed/22797180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2011111072
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