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Incorporation of 5-substituted uracil derivatives into nucleic acids. Part IV.The synthesis of 5-ethynyluracil.

5-Acetyluracil (I) has been treated with POCI3 to give 5-(1-chlorovinyl)-2,4-dichloropyrimidine (II). Treatment of II with KOEt gave a mixture of 2-ethoxy-5-ethynyl-4 (3H)-pyrimidinone (IIIA) and 4-ethoxy-5-ethynyl-2 (1H)-pyrimidinone (IIIB). IIIA and IIIB were isolated and characterised. The mixtur...

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Detalhes bibliográficos
Main Authors: Barr, P J, Jones, A S, Walker, R T
Formato: Artigo
Idioma:Inglês
Publicado em: 1976
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC343131/
https://ncbi.nlm.nih.gov/pubmed/995653
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