Design, synthesis, and anti-HIV-1 activity of 1-aromatic methyl-substituted 3-(3,5-dimethylbenzyl)uracil and N-3,5-dimethylbenzyl-substituted urea derivatives

BACKGROUND: A new series of 1-aromatic methyl-substituted 3-(3,5-dimethylbenzyl)uracil and N-3,5-dimethylbenzyl-substituted urea derivatives were synthesized and evaluated as non-nucleoside HIV-1 reverse transcriptase inhibitors. METHODS: A series of new 6-azido and 6-amino derivatives of 1-substitu...

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Detalhes bibliográficos
Publicado no:Antivir Chem Chemother
Main Authors: Sakakibara, Norikazu, Baba, Masanori, Okamoto, Mika, Toyama, Masaaki, Demizu, Yosuke, Misawa, Takashi, Kurihara, Masaaki, Irie, Kohji, Kato, Yoshihisa, Maruyama, Tokumi
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2015
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890500/
https://ncbi.nlm.nih.gov/pubmed/26149262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2040206614566584
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