A scalable pipeline for highly effective genetic modification of a malaria parasite

In malaria parasites the systematic experimental validation of drug and vaccine targets by reverse genetics is constrained by the inefficiency of homologous recombination and by the difficulty of manipulating adenine and thymine (AT) rich Plasmodium DNA in E. coli. We overcome these roadblocks by de...

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Detalhes bibliográficos
Main Authors: Pfander, Claudia, Anar, Burcu, Schwach, Frank, Otto, Thomas D., Brochet, Mathieu, Volkmann, Katrin, Quail, Michael A., Pain, Arnab, Rosen, Barry, Skarnes, William, Rayner, Julian C., Billker, Oliver
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431185/
https://ncbi.nlm.nih.gov/pubmed/22020067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.1742
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