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Cytokine-mediated β-cell damage in PARP-1-deficient islets
Poly(ADP)-ribose polymerase (PARP) is an abundant nuclear protein that is activated by DNA damage; once active, it modifies nuclear proteins through attachment of poly(ADP)-ribose units derived from β-nicotinamide adenine dinucleotide (NAD(+)). In mice, the deletion of PARP-1 attenuates tissue injur...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3431132/ https://ncbi.nlm.nih.gov/pubmed/22535743 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00055.2012 |
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