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Repair of Nitric Oxide-damaged DNA in β-Cells Requires JNK-dependent GADD45α Expression

Proinflammatory cytokines induce nitric oxide-dependent DNA damage and ultimately β-cell death. Not only does nitric oxide cause β-cell damage, it also activates a functional repair process. In this study, the mechanisms activated by nitric oxide that facilitate the repair of damaged β-cell DNA are...

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Detalhes bibliográficos
Main Authors: Hughes, Katherine J., Meares, Gordon P., Chambers, Kari T., Corbett, John A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785669/
https://ncbi.nlm.nih.gov/pubmed/19648647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.046912
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