Gadd45, a p53-Responsive Stress Protein, Modifies DNA Accessibility on Damaged Chromatin

This report demonstrates that Gadd45, a p53-responsive stress protein, can facilitate topoisomerase relaxing and cleavage activity in the presence of core histones. A correlation between reduced expression of Gadd45 and increased resistance to topoisomerase I and topoisomerase II inhibitors in a var...

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Detalhes bibliográficos
Main Authors: Carrier, France, Georgel, Philippe T., Pourquier, Philippe, Blake, Mellissa, Kontny, H. Udo, Antinore, Michael J., Gariboldi, Marzia, Myers, Timothy G., Weinstein, John N., Pommier, Yves, Fornace, Albert J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1999
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC83961/
https://ncbi.nlm.nih.gov/pubmed/10022855
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