Gadd45, a p53-Responsive Stress Protein, Modifies DNA Accessibility on Damaged Chromatin

This report demonstrates that Gadd45, a p53-responsive stress protein, can facilitate topoisomerase relaxing and cleavage activity in the presence of core histones. A correlation between reduced expression of Gadd45 and increased resistance to topoisomerase I and topoisomerase II inhibitors in a var...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Carrier, France, Georgel, Philippe T., Pourquier, Philippe, Blake, Mellissa, Kontny, H. Udo, Antinore, Michael J., Gariboldi, Marzia, Myers, Timothy G., Weinstein, John N., Pommier, Yves, Fornace, Albert J.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 1999
Schlagworte:	DNA Dynamics and Chromosome Structure
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC83961/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10022855/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.3.1673
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