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Heterodivalent Linked Macrocyclic β-Sheets with Enhanced Activity against Aβ Aggregation: Two Sites are Better than One
This paper reports a series of heterodivalent linked macrocyclic β-sheets 6 that are not only far more active against Aβ aggregation than their monovalent components 1a and 1b but also are dramatically more active than their homodivalent counterparts 4 and 5. The macrocyclic β-sheet components 1a an...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3430741/ https://ncbi.nlm.nih.gov/pubmed/22827298 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja305416a |
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