Nucleotide Excision DNA Repair is Associated with Age-Related Vascular Dysfunction

BACKGROUND: Vascular dysfunction in atherosclerosis and diabetes, as observed in the aging population of developed societies, is associated with vascular DNA damage and cell senescence. We hypothesized that cumulative DNA damage during aging contributes to vascular dysfunction. METHODS AND RESULTS:...

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Main Authors: Durik, Matej, Kavousi, Maryam, van der Pluijm, Ingrid, Isaacs, Aaron, Cheng, Caroline, Verdonk, Koen, Loot, Annemarieke E., Oeseburg, Hisko, Musterd-Bhaggoe, Usha, Leijten, Frank, van Veghel, Richard, de Vries, Rene, Rudez, Goran, Brandt, Renata, Ridwan, Yanto R., van Deel, Elza D., de Boer, Martine, Tempel, Dennie, Fleming, Ingrid, Mitchell, Gary F., Verwoert, Germaine C., Tarasov, Kirill V., Uitterlinden, Andre G., Hofman, Albert, Duckers, Henricus J., van Duijn, Cornelia M., Oostra, Ben A., Witteman, Jacqueline C.M., Duncker, Dirk J., Danser, A.H. Jan, Hoeijmakers, Jan H., Roks, Anton J.M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3430727/
https://ncbi.nlm.nih.gov/pubmed/22705887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.112.104380
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