Chronic Sildenafil Treatment Improves Vasomotor Function in a Mouse Model of Accelerated Aging

Aging leads to a loss of vasomotor control. Both vasodilation and vasoconstriction are affected. Decreased nitric oxide–cGMP-mediated relaxation is a hallmark of aging. It contributes to vascular disease, notably hypertension, infarction, and dementia. Decreased vasodilation can be caused by aging i...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Golshiri, Keivan, Ataei Ataabadi, Ehsan, Brandt, Renata, van der Pluijm, Ingrid, de Vries, René, Danser, A. H. Jan, Roks, Anton
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7369923/
https://ncbi.nlm.nih.gov/pubmed/32630010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21134667
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